Total Parenteral Nutrition Attenuates Cerulein-Induced Pancreatitis in Rats
نویسندگان
چکیده
منابع مشابه
Docosahexaenoic Acid Inhibits Cerulein-Induced Acute Pancreatitis in Rats
Oxidative stress is an important regulator in the pathogenesis of acute pancreatitis (AP). Reactive oxygen species induce activation of inflammatory cascades, inflammatory cell recruitment, and tissue damage. NF-κB regulates inflammatory cytokine gene expression, which induces an acute, edematous form of pancreatitis. Protein kinase C δ (PKCδ) activates NF-κB as shown in a mouse model of cerule...
متن کاملAntithrombin III prevents cerulein-induced acute pancreatitis in rats.
OBJECTIVES Systemic inflammatory mediators, including the protein high-mobility group box 1 (HMGB1), play an important role in the development of acute pancreatitis. Anticoagulants, such as antithrombin III (AT III), inhibit inflammation resulting from various causes, but their mechanism of action is not well understood. Because acute pancreatitis is a severe inflammatory disease, we hypothesiz...
متن کامل[Total enteral nutrition vs. total parenteral nutrition in patients with severe acute pancreatitis].
OBJECTIVE To compare the efficacy of early total enteral nutrition (TEN) vs. total parenteral nutrition (TPN) in patients with severe acute pancreatitis (SAP). METHODS A total of 22 consecutive patients with SAP were randomized to receive TPN (group I) or TEN (group II). SAP was defined applying APACHE II score, C-reactive protein (CRP) measurements and/or Balthazar CT scan score. Acute infla...
متن کاملNutrition Support in Pancreatitis: Beyond Parenteral Nutrition
19 INTRODUCTION P ancreatitis is caused by activation of pancreatic digestive enzymes within the pancreas leading to pain and inflammation (1). The inflammatory response to pancreatitis is similar to that of sepsis and can precipitate systemic inflammatory response syndrome (SIRS). SIRS can lead to multiple system organ failure, sepsis, hypermetabolism, hypercatabolism, and increased mortality ...
متن کاملMeta-analysis: total parenteral nutrition versus total enteral nutrition in predicted severe acute pancreatitis.
BACKGROUND Total parenteral nutrition (TPN) as a traditional mode of treatment in severe acute pancreatitis was still used widely in clinical work. In addition, enteral nutrition treatment methods have developed; early enteral nutrition has already been highlighted for severe acute pancreatitis, but the therapeutic risks versus benefits need to be studied. AIMS AND OBJECTIVE To compare total ...
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ژورنال
عنوان ژورنال: Pancreas
سال: 2010
ISSN: 0885-3177
DOI: 10.1097/mpa.0b013e3181bb908e